A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens
نویسندگان
چکیده
منابع مشابه
RNAi as a bioinformatics consumer
RNAi has shown great potential for use as a tool for biological discovery, analysis and therapeutics. The involvement of the RNAi pathway in post-transcription silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics throws up several bioinformatics challenges. This paper delineates several areas of research and reviews wor...
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Dynamical Cell Systems Laboratory, Division of Cancer Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK * Corresponding author. Dynamical Cell Systems Laboratory, Division of Cancer Biology, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. Tel.: þ 44 20 7153 5080; Fax: þ 44 20 7153 5177; E-mail: E-mail: chris.bakal@icr....
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2012
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.1898